Photoredox Catalysis

we have demonstrated the first C(sp3)−C(sp3) coupling of cycloalkanes with benzyl bromides and primary alkyl iodides via dual TBADT-nickel catalysis. Significantly, TBADT was successfully recovered and recycled up to five consecutive cycles, with no substantial decline in the yield of the coupled product.

Radical trap experiments identified transient radical species in the medium, leading to the hypotheses of a plausible mechanism.

Z-alkenes from alkynes

A protocol was developed to facilitate the hydroalkylation of terminal alkynes through the C−H activation of unactivated cyclic/acyclic alkanes. Our cobalt-HAT catalysis achieves the desired Z alkene with excellent regio- and diastereoselectivity via C−H activation.

Synthesis of ketones from primary amines

For the first time, we demonstrated a milder and efficient method for the cross-coupling of alkyl and aryl aldehydes with benzylic and allylic pyridinium salts via C−N bond cleavage. Site selectivity was achieved in the presence of various C−H bonds with similar BDEs. α- Amino and α-oxy methylene groups were intact.

© Dr. Ramesh Rasappan (Design & Maintenance).

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